Structure of PDB 4gtd Chain A

Receptor sequence
>4gtdA (length=210) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMEERDRHLIEYLMKHG
HETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSLSYEFYIPSPERLE
GYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPRRVARIVLPLNLYTR
FFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLK
YAYKGDILKE
3D structure
PDB4gtd Folate binding site of flavin-dependent thymidylate synthase.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A E86 S88 R144 R147 E84 S86 R137 R140
BS02 FAD A R78 H79 R80 I81 N169 L173 R174 H178 R76 H77 R78 I79 N162 L166 R167 H171
BS03 FAD A T55 E58 I81 N163 R165 T53 E56 I79 N156 R158
BS04 FAD A N85 E86 S88 N83 E84 S86
BS05 UMP A Q75 R78 R174 Q73 R76 R167
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gtd, PDBe:4gtd, PDBj:4gtd
PDBsum4gtd
PubMed23019356
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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