Structure of PDB 4gsn Chain A

Receptor sequence
>4gsnA (length=219) Species: 7165 (Anopheles gambiae) [Search protein sequence]
SNLVLYTLHLSPPCRAVELTAKALGLELEQKTINLLTGDHLKPEFVKLNP
QHTIPVLDDNGTIITESHAIMIYLVTKYGKDDSLYPKDPVKQARVNSALH
FESGVLFARMRFTFERILFFGKSDIPEDRVEYVQKSYELLEDTLVDDFVA
GPTMTIADFSCISTVSSIMGVVPLEQSKHPRIYAWIDRLKQLPYYEEVNG
GGGTDLGKFVLAKKEENAK
3D structure
PDB4gsn Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S12
Catalytic site (residue number reindexed from 1) S11
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A S12 P14 H41 H53 T54 I55 E67 S68 F108 S11 P13 H40 H52 T53 I54 E66 S67 F107
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:4gsn, PDBe:4gsn, PDBj:4gsn
PDBsum4gsn
PubMed24675797
UniProtQ9GPL8

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