Structure of PDB 4gsk Chain A

Receptor sequence
>4gskA (length=570) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SERVLSYAPAFKSFLDTSFFQELSRLKLDVTSQPLTVNLDLHNIPKSADQ
VPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFLHQRAL
ECWEDGIKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTVLHVRP
EPSLKGLFSKCQKWFDVNYSKWVCILDADDEIVNYDKSIIRKTKVLAIRD
TSTMENVPSALTKNFLSVLQYDVPDLIDFKLLIIRQNEGSFALNATFASP
DMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDLNLKLMKWRILPD
LNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVR
QALYNFEDAGKPKAELAAASLKRIFPLMDATGVKLSIPMIGHKLVNEEAQ
HKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIENKTVINAALGFDS
YLVMRHGQLGCYFCHRTLDQMCTVTRPGVAMMASSLAVELMTSLLQTKYS
GSETTVLGDIPHQIRGFLHNFSILKLETPAYEHCPACSPKVIEAFTDLGW
EFVKKALEHPLYLEEISGLS
3D structure
PDB4gsk Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C485 C488 C569 C572 C461 C464 C534 C537
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0019778 Atg12 activating enzyme activity
GO:0019779 Atg8 activating enzyme activity
GO:0042802 identical protein binding
Biological Process
GO:0000422 autophagy of mitochondrion
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0015031 protein transport
GO:0016236 macroautophagy
GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway
GO:0032446 protein modification by small protein conjugation
GO:0034727 piecemeal microautophagy of the nucleus
GO:0043412 macromolecule modification
GO:0044804 nucleophagy
Cellular Component
GO:0000407 phagophore assembly site
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0097632 extrinsic component of phagophore assembly site membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4gsk, PDBe:4gsk, PDBj:4gsk
PDBsum4gsk
PubMed23142976
UniProtP38862|ATG7_YEAST Ubiquitin-like modifier-activating enzyme ATG7 (Gene Name=ATG7)

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