Structure of PDB 4gs9 Chain A

Receptor sequence
>4gs9A (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
FKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYPQCIMCVN
YVLSEIE
3D structure
PDB4gs9 Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0XB A H248 M252 A277 Y281 S292 Y307 M309 T321 N341 H13 M17 A42 Y46 S57 Y72 M74 T86 N100 MOAD: Kd=2.2uM
BindingDB: Kd=2200nM
External links
PDB RCSB:4gs9, PDBe:4gs9, PDBj:4gs9
PDBsum4gs9
PubMed23363003
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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