Structure of PDB 4gry Chain A

Receptor sequence
>4gryA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGR
DSNIPGSDYINANYIKNQLLNAKTYIASQGCLEATVNDFWQMAWQENSRV
IVMTTREVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD
LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHSS
AGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ
YKFIYVAIAQFIETTKKKLEV
3D structure
PDB4gry Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
ChainA
Resolution1.6998 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D419 S453 R459 T460 Q500
Catalytic site (residue number reindexed from 1) D165 S199 R205 T206 Q246
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S453 A455 G458 R459 S199 A201 G204 R205
BS02 SO4 A H420 R459 H166 R205
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gry, PDBe:4gry, PDBj:4gry
PDBsum4gry
PubMed23296072
UniProtP29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (Gene Name=PTPN6)

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