Structure of PDB 4grv Chain A

Receptor sequence
>4grvA (length=454) Species: 10116,10665 [Search protein sequence]
NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKSLQSTVHYH
LGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYA
TALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPML
FTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISI
LNTVIANKLTVMVNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPS
LNAAKSELDKRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSL
DAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQ
TPNRAKRVITTFRTGTWDAYGSGSVQALRHGVLVARAVVIAFVVCWLPYH
VRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYASSAINPILYNLVSAN
FRQV
3D structure
PDB4grv Structure of the agonist-bound neurotensin receptor.
ChainA
Resolution2.802 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E223 D232
Enzyme Commision number ?
3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L55 F128 H132 Y146 R213 V224 T226 R327 R328 F331 S335 W339 F344 Y347 Y351 L4 F73 H77 Y91 R158 V169 T171 R402 R403 F406 S410 W414 F419 Y422 Y426
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:4grv, PDBe:4grv, PDBj:4grv
PDBsum4grv
PubMed23051748
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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