Structure of PDB 4grs Chain A

Receptor sequence
>4grsA (length=333) Species: 186497,243274 [Search protein sequence]
MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVA
DKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAG
PCSIESRDQIMKVAEFLAEVGIKVLRGGAFKPRTSPYSFQGYGEKALRWM
REAADEYGLVTVTEVMDTRHVELVAKYSDILQIGARNSQNFELLKEVGKV
ENPVLLKRGMGNTIQELLYSAEYIMAQGNENVILCERGIRTFETATRFTL
DISAVPVVKELSHLPIIVDPSHPAGRRSLVIPLAKAAYAIGADGIMVEVH
PEPEKALSDSQQQLTFDDFLQLLKELEALGWKG
3D structure
PDB4grs Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A M1 G40 I41 I42 G43 D45 M1 G40 I41 I42 G43 D45
BS02 TYR A S31 G33 E35 R36 V38 S31 G33 E35 R36 V38
Gene Ontology
Molecular Function
GO:0016832 aldehyde-lyase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4grs, PDBe:4grs, PDBj:4grs
PDBsum4grs
PubMed23345433
UniProtQ8U0A9;
Q9WYH8|AROF_THEMA Phospho-2-dehydro-3-deoxyheptonate aldolase (Gene Name=aroF)

[Back to BioLiP]