Structure of PDB 4gr5 Chain A

Receptor sequence
>4gr5A (length=451) Species: 47763 (Streptomyces lydicus) [Search protein sequence]
SNPFEEYDGGHVVLTDALGRHSLWPAGIAVPAGWSVRHGTDSREGCLAHI
EHHWTDLRPTRAPAGACVHELFEAQAARAPDAVALLHEADELTYGALNER
ANRLAHRLVGLGVAPGTLVGVHLERGFDMVVALLAVLKAGGGYTMLDPQF
PVERLALSLEDTGAPLLVTSRPLSGRLTGTTTLYVEDAGNLATGVGPEDV
ACVMFTSGSTGRPKGVMSPHRALTGTYLGQDYAGFGPDEVFLQCSPVSWD
AFGLELFGALLFGARCVLQSGQNPDPLEIGELVARHGVTMLQLSASLFNF
LVDEVPEAFEGVRYAITGGEPASVPHVAKARRDHPALRLGNGYGPAESMG
FTTHHAVVAGDLSGTALPIGVPLAGKRAYVLDDDLKPAANGALGELYVAG
AGLAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVG
R
3D structure
PDB4gr5 Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes.
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T219 T239 A359 E360
Catalytic site (residue number reindexed from 1) T206 T226 A346 E347
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A K227 W262 G332 E333 P334 N354 G355 Y356 P358 E360 D449 Y461 R464 K214 W249 G319 E320 P321 N341 G342 Y343 P345 E347 D436 Y448 R451
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0031177 phosphopantetheine binding
Biological Process
GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process
GO:0044550 secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4gr5, PDBe:4gr5, PDBj:4gr5
PDBsum4gr5
PubMed23192349
UniProtD1GLU5

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