Structure of PDB 4gq6 Chain A

Receptor sequence
>4gq6A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPVLTFQSEKMKGMKELLVATKIN
SSAIKLQLTAQSQVQMK
3D structure
PDB4gq6 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D136 R137 A138 D153 S155 D180 H181 F238 C241 L249 M278 Y319 Y323 E359 E363 D115 R116 A117 D132 S134 D159 H160 F217 C220 L228 M257 Y298 Y302 E338 E342
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4gq6, PDBe:4gq6, PDBj:4gq6
PDBsum4gq6
PubMed22936661
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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