Structure of PDB 4gq4 Chain A

Receptor sequence
>4gq4A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPPVLTFQSEKMKGMKELLVATKI
NSSAIKLQLTAQSQVQMK
3D structure
PDB4gq4 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
ChainA
Resolution1.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RT A S155 L177 S178 H181 F238 C241 Y276 M278 N282 Y319 Y323 S134 L156 S157 H160 F217 C220 Y255 M257 N261 Y298 Y302 PDBbind-CN: -logKd/Ki=7.66,Kd=22nM
BindingDB: IC50=190nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4gq4, PDBe:4gq4, PDBj:4gq4
PDBsum4gq4
PubMed22936661
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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