Structure of PDB 4gpu Chain A

Receptor sequence
>4gpuA (length=331) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence]
GSLVLSCKKFPHVSVNYVVDKTPKLLTDCKEVHNCSYIINDATLLWNEAS
RKPRLRPEVCTYIKDSKWENKAVKDSFIGIDLTKGYDDNSLVILKEAYQR
YEKTLNPEKTTFVSLRHHIIDIIMCPFLDEPLSLLMTVQPDKNILISVDN
KKICYTGFALEDLLIEHELYYSIVHGSLNDEIDLLIQAEMDSINTLTDTY
TEIKSSVHFKLGNTYHRRKLLRMWIQTNLLPKSDLLIGFRNSYSNELEQL
KAYKIQDIYHKINNSSIVGKPGKFYKFNPNVANDWFQHIFQVLKQNLLLL
SQESTSTTFKVQIDTNLTLSISPASQFVTAL
3D structure
PDB4gpu Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.-
3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E223 D262 E273 I274 E161 D191 E202 I203
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0034353 mRNA 5'-diphosphatase activity
GO:0046872 metal ion binding
GO:0110152 RNA NAD+-cap (NAD+-forming) hydrolase activity
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0071028 nuclear mRNA surveillance
GO:0090304 nucleic acid metabolic process
GO:0110155 NAD-cap decapping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gpu, PDBe:4gpu, PDBj:4gpu
PDBsum4gpu
PubMed22961381
UniProtQ6CPU0|DXO1_KLULA Decapping and exoribonuclease protein 1 (Gene Name=DXO1)

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