Structure of PDB 4gnd Chain A

Receptor sequence
>4gndA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
PKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH
QCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP
3D structure
PDB4gnd The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1324 C1327 H1346 C1349 C9 C12 H31 C34
BS02 ZN A C1336 C1341 C1362 H1365 C21 C26 C47 H50
BS03 ZN A C1378 C1381 C1405 H1408 C63 C66 C90 H93
BS04 ZN A C1367 C1386 H1389 C52 C71 H74
External links
PDB RCSB:4gnd, PDBe:4gnd, PDBj:4gnd
PDBsum4gnd
PubMed23269674
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

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