Structure of PDB 4gna Chain A

Receptor sequence
>4gnaA (length=297) Species: 10090 (Mus musculus) [Search protein sequence]
SIKVECVLRENYRCGESPVWEEASQSLLFVDIPSKIICRWDTVSNQVQRV
AVDAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDEDKKNNRF
NDGKVDPAGRYFAGTMAEETAPAVLERHQGSLYSLFPDHSVKKYFDQVDI
SNGLDWSLDHKIFYYIDSLSYTVDAFDYDLQTGQISNRRIVYKMEKDEQI
PDGMCIDAEGKLWVACYNGGRVIRLDPETGKRLQTVKLPVDKTTSCCFGG
KDYSEMYVTCARDGLNAEGLLRQPDAGNIFKITGLGVKGIAPYSYAG
3D structure
PDB4gna Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.17: gluconolactonase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E18 N154 D204 E16 N152 D202
BS02 XYL A E18 R101 N103 E121 N154 D204 Y219 E16 R99 N101 E119 N152 D202 Y217
Gene Ontology
Molecular Function
GO:0004341 gluconolactonase activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030234 enzyme regulator activity
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0001889 liver development
GO:0006874 intracellular calcium ion homeostasis
GO:0007283 spermatogenesis
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010907 positive regulation of glucose metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0032781 positive regulation of ATP-dependent activity
GO:0043066 negative regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050848 regulation of calcium-mediated signaling
GO:0097421 liver regeneration
GO:1901318 negative regulation of flagellated sperm motility
GO:1902679 negative regulation of RNA biosynthetic process
GO:1903011 negative regulation of bone development
GO:1903052 positive regulation of proteolysis involved in protein catabolic process
GO:1903625 negative regulation of DNA catabolic process
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gna, PDBe:4gna, PDBj:4gna
PDBsum4gna
PubMed23349732
UniProtQ64374|RGN_MOUSE Regucalcin (Gene Name=Rgn)

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