Structure of PDB 4gmz Chain A

Receptor sequence
>4gmzA (length=612) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEE
EYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRD
TVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGS
PLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLP
LKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIA
SRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLP
GWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTI
QKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAH
PNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQ
HGVFVGAAMRSEGGIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPK
IFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPK
EDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIER
ELRALKQRISQM
3D structure
PDB4gmz The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R87 Y235 K244 H264 S286 C288 D311 R405
Catalytic site (residue number reindexed from 1) R86 Y234 K243 H263 S285 C287 D310 R404
Enzyme Commision number 2.7.11.-
4.1.1.32: phosphoenolpyruvate carboxykinase (GTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S286 A287 G289 K290 T291 N292 R405 R436 W516 F517 F525 G529 F530 S285 A286 G288 K289 T290 N291 R404 R435 W506 F507 F515 G519 F520
BS02 MN A K244 H264 K290 D311 K243 H263 K289 D310
BS03 SPV A R87 G237 K243 K244 H264 S286 R405 R86 G236 K242 K243 H263 S285 R404
Gene Ontology
Molecular Function
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0017076 purine nucleotide binding
Biological Process
GO:0006094 gluconeogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:4gmz, PDBe:4gmz, PDBj:4gmz
PDBsum4gmz
PubMed23127136
UniProtP07379|PCKGC_RAT Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (Gene Name=Pck1)

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