Structure of PDB 4gmw Chain A

Receptor sequence
>4gmwA (length=611) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEE
EYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRD
TVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGS
PLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLP
LKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIA
SRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLP
GWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTI
QKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAH
PNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQ
HGVFVGAAMRSEGIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKI
FHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKE
DALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERE
LRALKQRISQM
3D structure
PDB4gmw The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R87 Y235 K244 H264 S286 C288 D311 R405
Catalytic site (residue number reindexed from 1) R86 Y234 K243 H263 S285 C287 D310 R404
Enzyme Commision number 2.7.11.-
4.1.1.32: phosphoenolpyruvate carboxykinase (GTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A A287 G289 K290 T291 N292 R436 W516 F517 F525 G529 F530 A286 G288 K289 T290 N291 R435 W505 F506 F514 G518 F519
BS02 MN A K244 H264 D311 K243 H263 D310
BS03 PEP A R87 Y235 G236 G237 R405 R86 Y234 G235 G236 R404
BS04 MN A H502 E607 H491 E596
Gene Ontology
Molecular Function
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0017076 purine nucleotide binding
Biological Process
GO:0006094 gluconeogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:4gmw, PDBe:4gmw, PDBj:4gmw
PDBsum4gmw
PubMed23127136
UniProtP07379|PCKGC_RAT Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (Gene Name=Pck1)

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