Structure of PDB 4gmu Chain A

Receptor sequence
>4gmuA (length=610) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEE
YGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDT
VPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSP
LAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPL
KKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIAS
RLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPG
WKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQ
KNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHP
NSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQH
GVFVGAAMRSEGIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIF
HVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKED
ALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIEREL
RALKQRISQM
3D structure
PDB4gmu The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function.
ChainA
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R87 Y235 K244 H264 S286 C288 D311 R405
Catalytic site (residue number reindexed from 1) R85 Y233 K242 H262 S284 C286 D309 R403
Enzyme Commision number 2.7.11.-
4.1.1.32: phosphoenolpyruvate carboxykinase (GTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S286 A287 G289 K290 T291 N292 V335 R405 W516 F517 F525 G529 F530 S284 A285 G287 K288 T289 N290 V333 R403 W504 F505 F513 G517 F518
BS02 MN A K244 H264 K290 D311 K242 H262 K288 D309
BS03 OXL A R87 K244 H264 S286 D311 R405 R85 K242 H262 S284 D309 R403
Gene Ontology
Molecular Function
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0017076 purine nucleotide binding
Biological Process
GO:0006094 gluconeogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:4gmu, PDBe:4gmu, PDBj:4gmu
PDBsum4gmu
PubMed23127136
UniProtP07379|PCKGC_RAT Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (Gene Name=Pck1)

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