Structure of PDB 4glx Chain A

Receptor sequence
>4glxA (length=573) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPEL
ITPDSPTQRPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRTWCCE
LKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGEN
IPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPR
ITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESA
EEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAF
KFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADE
IERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGS
DVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLV
EKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLY
ALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNF
FAEESNRNVISELLAEGVHWPAP
3D structure
PDB4glx Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y225 T427
Catalytic site (residue number reindexed from 1) Y212 T414
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003911 DNA ligase (NAD+) activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4glx, PDBe:4glx, PDBj:4glx
PDBsum4glx
PubMed23006603
UniProtP15042|DNLJ_ECOLI DNA ligase (Gene Name=ligA)

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