Structure of PDB 4gkv Chain A

Receptor sequence
>4gkvA (length=336) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGD
KTGVILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNE
TLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTT
YKAVKLSKIRPGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLK
LATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKAAFNSAVDAVR
AGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
3D structure
PDB4gkv Structure of Escherichia coli AdhP (ethanol-inducible dehydrogenase) with bound NAD.
ChainA
Resolution2.008 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C37 H38 T39 H42 H58 E59 C89 C92 C95 C103 K107 C145 T149 R329
Catalytic site (residue number reindexed from 1) C37 H38 T39 H42 H58 E59 C89 C92 C95 C103 K107 C145 T149 R329
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A C37 H38 T39 H42 C145 T149 G169 G171 G172 L173 D193 Q198 A236 V237 V258 G259 L260 L283 V284 R329 C37 H38 T39 H42 C145 T149 G169 G171 G172 L173 D193 Q198 A236 V237 V258 G259 L260 L283 V284 R329
BS02 ZN A C37 H58 C145 C37 H58 C145
BS03 ZN A C89 C92 C95 C103 C89 C92 C95 C103
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0047639 alcohol oxidase activity
Biological Process
GO:0006974 DNA damage response
GO:0045471 response to ethanol
GO:0046187 acetaldehyde catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4gkv, PDBe:4gkv, PDBj:4gkv
PDBsum4gkv
PubMed23832197
UniProtP39451|ADHP_ECOLI Alcohol dehydrogenase, propanol-preferring (Gene Name=adhP)

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