Structure of PDB 4gk3 Chain A

Receptor sequence
>4gk3A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
VHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG
YTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLD
SFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNL
VCKVSDFGLSRVLIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGE
RPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFE
QIVSILDKLIRNPGSLKIITSNLLL
3D structure
PDB4gk3 Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
ChainA
Resolution1.898 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D746 A748 R750 N751 D764
Catalytic site (residue number reindexed from 1) D138 A140 R142 N143 D156
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L87 A A651 K653 E670 M674 T699 Y701 M702 G705 L753 S763 A43 K45 E62 M66 T91 Y93 M94 G97 L145 S155 PDBbind-CN: -logKd/Ki=7.25,IC50=56nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gk3, PDBe:4gk3, PDBj:4gk3
PDBsum4gk3
PubMed23253074
UniProtP29320|EPHA3_HUMAN Ephrin type-A receptor 3 (Gene Name=EPHA3)

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