Structure of PDB 4gj3 Chain A

Receptor sequence
>4gj3A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ
HRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY
LPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKI
GDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK
CPAEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYR
3D structure
PDB4gj3 Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 E1050 P1064
Catalytic site (residue number reindexed from 1) N134 A136 R138 N139 D152 E161 P175
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0XP A R901 L903 G904 E905 V911 Y980 V981 P982 G984 R1027 N1028 L1030 G1040 D1041 R12 L14 G15 E16 V22 Y91 V92 P93 G95 R138 N139 L141 G151 D152 MOAD: Ki=1.4nM
PDBbind-CN: -logKd/Ki=8.85,Ki=1.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gj3, PDBe:4gj3, PDBj:4gj3
PDBsum4gj3
PubMed23668484
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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