Structure of PDB 4gih Chain A

Receptor sequence
>4gihA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ
HRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY
LPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKI
GDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGV
TLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK
CPAEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYR
3D structure
PDB4gih Lead identification of novel and selective TYK2 inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 E1050 P1064
Catalytic site (residue number reindexed from 1) N134 A136 R138 N139 D152 E161 P175
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0X5 A L903 G904 E905 V911 I960 Y980 V981 G984 L1030 L14 G15 E16 V22 I71 Y91 V92 G95 L141 MOAD: Ki=0.0048uM
PDBbind-CN: -logKd/Ki=8.32,Ki=0.0048uM
BindingDB: Ki=4.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gih, PDBe:4gih, PDBj:4gih
PDBsum4gih
PubMed23867602
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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