Structure of PDB 4ght Chain A

Receptor sequence
>4ghtA (length=181) Species: 39054 (Enterovirus A71) [Search protein sequence]
MGPSLDFALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWI
EHKLVNILDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASD
ATLVINTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGG
VVTSVGKVIGIHIGGNGRQGFCAGLKRSYFA
3D structure
PDB4ght Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir
ChainA
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H41 E72 G146 C148
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG7 A R39 H40 E71 L125 N126 L127 S128 K130 T142 K143 A144 C147 H161 I162 G163 G164 N165 F170 R40 H41 E72 L126 N127 L128 S129 K131 T143 K144 A145 C148 H162 I163 G164 G165 N166 F171 PDBbind-CN: -logKd/Ki=5.78,IC50=1.67uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ght, PDBe:4ght, PDBj:4ght
PDBsum4ght
PubMed23633597
UniProtA9XG43

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