Structure of PDB 4ghi Chain A

Receptor sequence
>4ghiA (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
FKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYPQCIMCVN
YVLSEIE
3D structure
PDB4ghi Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0X3 A F244 H248 M252 F254 Y281 S292 L296 S304 Y307 M309 T321 C339 N341 F9 H13 M17 F19 Y46 S57 L61 S69 Y72 M74 T86 C98 N100 MOAD: Kd=81nM
PDBbind-CN: -logKd/Ki=7.09,Kd=81nM
BindingDB: Kd=90nM,IC50=490nM
External links
PDB RCSB:4ghi, PDBe:4ghi, PDBj:4ghi
PDBsum4ghi
PubMed23434853
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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