Structure of PDB 4gh5 Chain A

Receptor sequence
>4gh5A (length=248) Species: 78245 (Xanthobacter autotrophicus Py2) [Search protein sequence]
NRLKNEVIAITGGGAGIGLAIASAALREGAKVALIDLDQGLAERSAAMLS
TGGAVAKGFGADVTKAADITAAITSAEQTIGSLTGLVNNAGIAGFGSVHD
ADAAAWDRIMAVNVTGTFLASKAALAGMLERHKGTIVNFGSVAGLVGIPT
MAAYCAAKGAIVNLTRQMAADYSGRGVRVNAVCPGTVTSTGMGQQLLPEV
QARRLAKYPIGRFGTPEDIAEAVIFLLSDQAAFVTGAAFAVDGGMTAI
3D structure
PDB4gh5 Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G18 N115 S143 Y156 K160
Catalytic site (residue number reindexed from 1) G16 N113 S141 Y154 K158
Enzyme Commision number 1.1.1.269: 2-(S)-hydroxypropyl-CoM dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G14 G18 I19 D38 L39 A63 D64 V65 N91 A92 V114 F141 S143 Y156 K160 P186 V189 T192 G193 M194 G12 G16 I17 D36 L37 A61 D62 V63 N89 A90 V112 F139 S141 Y154 K158 P184 V187 T190 G191 M192
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:4gh5, PDBe:4gh5, PDBj:4gh5
PDBsum4gh5
PubMed23474457
UniProtA7IQH5|HCDS3_XANP2 2-(S)-hydroxypropyl-CoM dehydrogenase 3 (Gene Name=xecE3)

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