Structure of PDB 4gg7 Chain A

Receptor sequence
>4gg7A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
QAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN
RIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLR
NFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKF
TVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDV
WSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM
LKCWHPKAEMRPSFSELVSRISAIFSTF
3D structure
PDB4gg7 Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
ChainA
Resolution2.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D138 A140 R142 N143 D156 A177
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0J8 A I1084 L1157 M1160 K1161 G1163 R1208 M1211 A1221 D1222 Y1230 I21 L91 M94 K95 G97 R142 M145 A155 D156 Y164 MOAD: ic50=6.5nM
PDBbind-CN: -logKd/Ki=8.20,Ki=6.3nM
BindingDB: IC50=6.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gg7, PDBe:4gg7, PDBj:4gg7
PDBsum4gg7
PubMed22985853
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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