Structure of PDB 4gg5 Chain A

Receptor sequence
>4gg5A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
QAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN
RITDIQFLTEGIIMKDFSHPNVLSLLGICLRSPLVVLPYMKHGDLRNFIR
NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKV
ADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFG
VLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTF
3D structure
PDB4gg5 Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.
ChainA
Resolution2.423 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 A173
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0J3 A I1084 L1157 Y1159 M1160 R1208 N1209 M1211 A1221 D1222 Y1230 I21 L87 Y89 M90 R138 N139 M141 A151 D152 Y160 MOAD: ic50=0.93nM
PDBbind-CN: -logKd/Ki=9.03,IC50=0.93nM
BindingDB: IC50=0.930000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gg5, PDBe:4gg5, PDBj:4gg5
PDBsum4gg5
PubMed22985853
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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