Structure of PDB 4gfv Chain A

Receptor sequence
>4gfvA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
DSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPE
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQ
GPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTG
LFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPPDHM
LAMVEEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPD
FSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
3D structure
PDB4gfv PTPN18-HER2 peptides
ChainA
Resolution2.095 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D197 S229 R235 T236 Q276
Catalytic site (residue number reindexed from 1) D192 S222 R228 T229 Q269
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y62 D64 V65 D197 R198 S229 S230 A231 G232 C233 G234 R235 Q276 Y57 D59 V60 D192 R193 S222 S223 A224 G225 C226 G227 R228 Q269
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gfv, PDBe:4gfv, PDBj:4gfv
PDBsum4gfv
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

[Back to BioLiP]