Structure of PDB 4gfo Chain A

Receptor sequence
>4gfoA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALWKQEIDI
LRTLYHEHIIKYKGCCELQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ
ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYR
VREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPT
KFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEA
SFRPTFENLIPILKTVHEKYRH
3D structure
PDB4gfo Lead identification of novel and selective TYK2 inhibitors.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N117 A119 R121 N122 D135 P158
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0X2 A L903 G904 E905 G906 V911 A928 E979 Y980 V981 N1028 L1030 L14 G15 E16 G17 V22 A39 E73 Y74 V75 N122 L124 MOAD: Ki=0.24uM
PDBbind-CN: -logKd/Ki=6.62,Ki=0.24uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gfo, PDBe:4gfo, PDBj:4gfo
PDBsum4gfo
PubMed23867602
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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