Structure of PDB 4geg Chain A

Receptor sequence
>4gegA (length=258) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LVPRGSMILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLY
VDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGFSLGGRVAMM
AACQGLAGLCGVIVEGGHPGLQNAEQRAERQRSDRQWVQRFLTEPLTAVF
ADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRAN
LSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIA
SLAQILRF
3D structure
PDB4geg Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
ChainA
Resolution2.49 Å
3D
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Enzymatic activity
Enzyme Commision number 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S86 L87 R90 S92 L93 R96
BS02 SO4 A G60 D62 G66 D68
BS03 SO4 A R198 A201 F202 Y203 R204 A207 F208 Y209
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0070205 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4geg, PDBe:4geg, PDBj:4geg
PDBsum4geg
PubMed23637813
UniProtP37355|MENH_ECOLI 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (Gene Name=menH)

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