Structure of PDB 4ge5 Chain A

Receptor sequence
>4ge5A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPG
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQ
GPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSS
AASLIDFLRVVRNQQSLAVSNMEPPIVVHCSAGIGRTGTFCSLDICLAQL
EELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSA
3D structure
PDB4ge5 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D470 C515 R521 T522 Q559
Catalytic site (residue number reindexed from 1) D194 C230 R236 T237 Q274
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A89 A R311 Y333 D335 C515 S516 A517 I519 G520 R521 F556 Q559 R35 Y57 D59 C230 S231 A232 I234 G235 R236 F271 Q274 MOAD: ic50=0.27uM
PDBbind-CN: -logKd/Ki=6.57,IC50=0.27uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ge5, PDBe:4ge5, PDBj:4ge5
PDBsum4ge5
PubMed23075115
UniProtP43378|PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (Gene Name=PTPN9)

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