Structure of PDB 4gcm Chain A

Receptor sequence
>4gcmA (length=308) Species: 196620 (Staphylococcus aureus subsp. aureus MW2) [Search protein sequence]
EIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENF
PGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKEL
TAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGG
GDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHT
LKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGI
TNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAE
YIEHLNDQ
3D structure
PDB4gcm Crystal structure of a thioredoxine reductase (trxB) from Staphylococcus aureus subsp. aureus Mu50 at 1.80 A resolution
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C134 C137 D138
Catalytic site (residue number reindexed from 1) C132 C135 D136
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G12 G14 P15 A16 E35 R36 G41 Q42 T46 N51 D82 I83 T111 G112 C137 G276 D277 Q285 I286 G10 G12 P13 A14 E33 R34 G39 Q40 T44 N49 D80 I81 T109 G110 C135 G274 D275 Q283 I284
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:4gcm, PDBe:4gcm, PDBj:4gcm
PDBsum4gcm
PubMed
UniProtP66011|TRXB_STAAW Thioredoxin reductase (Gene Name=trxB)

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