Structure of PDB 4gbr Chain A

Receptor sequence
>4gbrA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACA
DLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIA
VDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATH
QEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR
QLQKIDKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKE
VYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL
3D structure
PDB4gbr N-terminal t4 lysozyme fusion facilitates crystallization of a g protein coupled receptor.
ChainA
Resolution3.993 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAU A W109 D113 V114 F193 S203 W258 F261 F262 N265 N284 Y288 W81 D85 V86 F165 S175 W230 F233 F234 N237 N256 Y260 BindingDB: Ki=0.030000nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004941 beta2-adrenergic receptor activity
Biological Process
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4gbr, PDBe:4gbr, PDBj:4gbr
PDBsum4gbr
PubMed23056231
UniProtP07550|ADRB2_HUMAN Beta-2 adrenergic receptor (Gene Name=ADRB2)

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