Structure of PDB 4gaa Chain A

Receptor sequence
>4gaaA (length=606) Species: 8355 (Xenopus laevis) [Search protein sequence]
ADPSSFASPEKFNIKHMHLKLHVDFTSRAIAASTSLTVRSLQDSLASLIL
DTKDLTIKKVAVNGKDATFALGTTHSFKGTPLEITLPFSLTRGQEVIVEI
DSVTSPKSSALQWLNKEQTAGKIHPYLFSQCQATHCRSIIPCQDTPSVKF
TYYSQVSVPKELMALMSALRDGELSEQSDSNRKIYRFKQNVPIPSYLIAL
VVGALEGRKVGPRTTIWTEKELLEPSVYEFAETEKMLKYAEDLAGPYVWG
QYDLLILPPSFPYGGMENPCLTFVTPTVLAGDRSLASVIAHEISHSWTGN
LVTNETWENFWLNEGHTVYLERRIDGRLYGEEFRQFKALGGWKELQNSVN
TFGATNPLTNLVPNLHEVDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFL
GFLKSYIQMFAFKSVTTEEWKKFLYSYFKDKVDILDKVDWKGWMHTPGMP
PVQPKYDMTLANACITLGQKWVKATESDLGSFSADDVKDLSSHQLIEVLA
ILLLEKPLPVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAGWEDVIPLA
LAMATEQGRMKFTRPLYRDLYNFEKAREQTVNTFLKNRSFMHPVTEMLVA
KDLHIS
3D structure
PDB4gaa Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
ChainA
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E268 H292 E293 H296 E315 D372 Y380
Catalytic site (residue number reindexed from 1) E267 H291 E292 H295 E314 D371 Y379
Enzyme Commision number 3.3.2.6: leukotriene-A4 hydrolase.
3.4.11.4: tripeptide aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H292 H296 E315 H291 H295 E314
BS02 BES A Q133 Y264 G265 G266 E268 V289 H292 E293 H296 E315 F375 Y380 Q132 Y263 G264 G265 E267 V288 H291 E292 H295 E314 F374 Y379
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004301 epoxide hydrolase activity
GO:0004463 leukotriene-A4 hydrolase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019370 leukotriene biosynthetic process
GO:0043171 peptide catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gaa, PDBe:4gaa, PDBj:4gaa
PDBsum4gaa
PubMed24333438
UniProtQ6IP81|LKHA4_XENLA Leukotriene A-4 hydrolase (Gene Name=lta4h.L)

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