Structure of PDB 4g8l Chain A

Receptor sequence
>4g8lA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHN
AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG
ADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLR
GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD
VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIN
DTDSDGKTALLLAVELKLKKIAELLCKRGASTCGDLVMTARRNYDHSLVK
VLLSHGA
3D structure
PDB4g8l Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25A A E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155 E40 E42 G43 W45 Q53 K74 Y109 F111 E116 Y120 R140 PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
BindingDB: IC50=20nM,EC50=0.210000nM
BS02 25A A M306 R309 R310 Y312 M288 R291 R292 Y294 PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
BindingDB: IC50=20nM,EC50=0.210000nM
External links
PDB RCSB:4g8l, PDBe:4g8l, PDBj:4g8l
PDBsum4g8l
PubMed23084743
UniProtQ05823|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

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