Structure of PDB 4g72 Chain A

Receptor sequence

>4g72A (length=549) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

YEAYPEKKATLYFLVLGFLALIVGSLFGPFQALNYGNVDAYPLLKRLLPF
VQSYYQGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWLSWW
MAFIGLVVFALPLLANEATVLYTFYPPLKGHWAFYLGASVFVLSTWVSIY
IVLDLWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAVLFLLPW
SFGLVEGVDPLVARTLFWWTGHPIMYFWLLPAYAIIYTILPKQAGGKLVS
DPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLTLFVAVPSLM
TAFTVAASLEFAGRLRGGRGLFGWIRALPWDNPAFVAPVLGLLGFIPGGA
GGIVNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLLPNLTGK
PISDAQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNVPRRAYIAQVPDAYP
HAAVPMVFNVLAGIVLLVALLLFIYGLFSVLLSRKPELAEAPLPFAEVIS
GPEDRRLVLAMDRIGFWFAVAAILVVLAYGPTLVQLFGHLNPVPGWRLW

3D structure

PDB

4g72 Structure of Recombinant Cytochrome ba3 Oxidase mutant V236M from Thermus thermophilus

Chain

Resolution

3.19 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H72 P101 Y133 S155 T156 H233 I235 Y237 Y248 H282 H283 S309 G331 H384 F385 H386 R449 R450
Catalytic site (residue number reindexed from 1)	H61 P90 Y122 S144 T145 H222 I224 Y226 Y237 H271 H272 S298 G320 H373 F374 H375 R438 R439
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	A	H233 H282 H283	H222 H271 H272
BS02	HEM	A	G39 P40 Q42 Y46 Y65 L69 H72 N76 Y133 F385 H386 V389 A390 M432 R450 L477	G28 P29 Q31 Y35 Y54 L58 H61 N65 Y122 F374 H375 V378 A379 M421 R439 L466
BS03	HAS	A	Y133 W229 M236 Y237 H282 H283 S309 A313 V350 L353 F356 G363 N366 A367 D372 H376 H384 F385 Q388 V389 R449	Y122 W218 M225 Y226 H271 H272 S298 A302 V339 L342 F345 G352 N355 A356 D361 H365 H373 F374 Q377 V378 R438

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4g72, PDBe:4g72, PDBj:4g72
PDBsum	4g72
PubMed
UniProt	Q5SJ79\|COX1_THET8 Cytochrome c oxidase subunit 1 (Gene Name=cbaA)

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