Structure of PDB 4g3g Chain A

Receptor sequence
>4g3gA (length=312) Species: 10090 (Mus musculus) [Search protein sequence]
SGSVSSGQAHSLASLAKTWSGPETEDNEGVLLTEKLKPVDYEYREEVHWM
THQPRLGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSP
RIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQAL
EGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLDYIPGTETH
MAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEP
PPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLK
SPWKGEYKEPRG
3D structure
PDB4g3g The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 K519 N522 D536 T561
Catalytic site (residue number reindexed from 1) D165 K167 N170 D184 T197
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0WA A L408 V416 A429 V430 K431 E442 I469 M471 L524 C535 D536 L56 V64 A77 V78 K79 E90 I117 M119 L172 C183 D184 PDBbind-CN: -logKd/Ki=8.43,Ki=3.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4g3g, PDBe:4g3g, PDBj:4g3g
PDBsum4g3g
PubMed22921830
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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