Structure of PDB 4g36 Chain A

Receptor sequence
>4g36A (length=522) Species: 7054 (Photinus pyralis) [Search protein sequence]
AKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITY
AEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVA
PANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMD
SKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSLPKGV
ALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLIC
GFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSN
LHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDK
PGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEAT
NALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESIL
LDAGVAGLPDDDAGELPAAVVVLETEKEIVDYVASQVTTAKKLRGGVVFV
DEVPKGLTGKLDARKIREILIK
3D structure
PDB4g36 Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism.
ChainA
Resolution2.624 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S198 R218 H245 T343 E344 K443 Q448 K529
Catalytic site (residue number reindexed from 1) S195 R210 H237 T335 E336 K435 Q440 K510
Enzyme Commision number 1.13.12.7: firefly luciferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLU A H245 F247 G315 G316 A317 P318 Q338 G339 Y340 G341 L342 T343 S347 A348 D422 R437 K529 H237 F239 G307 G308 A309 P310 Q330 G331 Y332 G333 L334 T335 S339 A340 D414 R429 K510
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0004497 monooxygenase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0008218 bioluminescence
GO:0046949 fatty-acyl-CoA biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Cellular Component
External links
PDB RCSB:4g36, PDBe:4g36, PDBj:4g36
PDBsum4g36
PubMed22852753
UniProtP08659|LUCI_PHOPY Luciferin 4-monooxygenase

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