Structure of PDB 4g33 Chain A

Receptor sequence
>4g33A (length=661) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
ANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRA
VLTSKKLVYVWTENFANVKGVPMARSVPLGELPNVDWLLKTAGVIVELIV
NFVASLPASAAAQFERIAAGLSGDLEAARQVHEALLEEAKNDPAAAGSLL
LRFTELQTRVIALLTRVGLLVDDILKSASNLVDGLNRFRAVFGTLRLPEV
ADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSL
LEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRA
GLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEM
FVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARIL
LPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPAA
LPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIG
SGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICA
MSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYR
QTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRKPYEYL
LPSRIPASTNI
3D structure
PDB4g33 Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa.
ChainA
Resolution2.03 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H377 H382 H555 N559 I685
Catalytic site (residue number reindexed from 1) H353 H358 H531 N535 I661
Enzyme Commision number 1.13.11.12: linoleate 13S-lipoxygenase.
1.13.11.58: linoleate 9S-lipoxygenase.
1.13.11.77: oleate 10S-lipoxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H377 H382 H555 N559 I685 H353 H358 H531 N535 I661
BS02 ZPE A T109 L182 D190 E373 H377 H382 F415 A420 L424 N607 Y609 T91 L164 D172 E349 H353 H358 F391 A396 L400 N583 Y585
Gene Ontology
Molecular Function
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0034440 lipid oxidation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4g33, PDBe:4g33, PDBj:4g33
PDBsum4g33
PubMed23985801
UniProtQ8RNT4|LOX_PSEAI Linoleate 9/13-lipoxygenase (Gene Name=lox)

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