Structure of PDB 4g2i Chain A

Receptor sequence
>4g2iA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
LRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSVTLE
LSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEV
IMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGL
KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR
HPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFG
3D structure
PDB4g2i Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0VQ A Y143 L227 L233 V234 S237 R274 S275 S278 W286 H305 L313 H397 Y401 Y24 L57 L63 V64 S67 R104 S105 S108 W116 H135 L143 H227 Y231 BindingDB: EC50=1.7nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4g2i, PDBe:4g2i, PDBj:4g2i
PDBsum4g2i
PubMed22957834
UniProtP11473|VDR_HUMAN Vitamin D3 receptor (Gene Name=VDR)

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