Structure of PDB 4g2c Chain A

Receptor sequence

>4g2cA (length=462) Species: 385957 (Amycolatopsis sp. ATCC 39116)

VDLSTTLSWKSATGEAATMLDELQPNILKAHVRDRLTVLFLGFGDAAEAR
TFLNGLSGLMKSARTHLQEVEAHKLTKAVGTPYLGVGLTAHGYATLGVTA
PADPSFTAGAKAAVEKLADPAVTEWEGHYQQTIDAVLLLGDATAGPVRTL
RRQVEALRPASVTVVGEESGLGLANANGDGIEHFGYVDGRSQPLFLTEDV
DAERDTTDGVNDWDPSAPLEQVLVPDPAAPDPTVHFGSYFVFRKLEQNVR
LFKEAERDLAHDLGLRGEDRERAGAMLVGRFEDGTPLTAQSAPGSHHPVG
NDFSYDSDKLGQKCPFHAHIRKTNPRGSGGAEAPEEERKHLMARRGQTYG
RRHDDPNADLPPRLRPAKDVGLLFMAFNSNLGNQFEFTQQIWANNPAFPF
PPDGSQPGLDPVIGQGARAPQKYAPEWGHNNVAEATDPIPQAVTMKGGEY
FFMPSLAFLRSL

3D structure

• PDB: 4g2c Identification and characterization of a multifunctional dye peroxidase from a lignin-reactive bacterium.
• Chain: A
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 1.11.1.16: versatile peroxidase.
  1.11.1.19: dye decolorizing peroxidase.
  1.11.1.7: peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	E186 V191 D192 G193 R194 S195 Q251 H323 I324 T327 N328 R330 R348 F378 F389 T392 Q393 I417	E182 V187 D188 G189 R190 S191 Q247 H319 I320 T323 N324 R326 R344 F374 F385 T388 Q389 I413
BS02	MN	A	E260 E286	E256 E282

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0016689 manganese peroxidase activity
• GO:0020037 heme binding
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0052750 reactive-black-5:hydrogen-peroxide oxidoreductase activity
• GO:0140825 lactoperoxidase activity

Biological Process

• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0005576 extracellular region
• GO:0005829 cytosol

External links

• PDB: RCSB:4g2c, PDBe:4g2c, PDBj:4g2c
• PDBsum: 4g2c
• PubMed: 23054399
• UniProt: K7N5M8|DYP2_AMYS7 Multifunctional dye peroxidase DyP2 (Gene Name=dyp2)