Structure of PDB 4g1w Chain A

Receptor sequence
>4g1wA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG
VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFE
KLFPDVLFPLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSE
AEAPPREHTIEEWKELIYKEVM
3D structure
PDB4g1w Crystal structure of JNK1 in complex with JIP1 peptide and inhibitor
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162 T166
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R127 S161 D162 C163 W324 E329 R120 S154 D155 C156 W295 E300
BS02 G1W A I32 G33 V40 A53 E109 L110 M111 D112 A113 N114 V158 L168 I25 G26 V33 A46 E102 L103 M104 D105 A106 N107 V151 L161 BindingDB: IC50=58nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4g1w, PDBe:4g1w, PDBj:4g1w
PDBsum4g1w
PubMed
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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