Structure of PDB 4g1v Chain A

Receptor sequence

>4g1vA (length=398) Species: 307796 (Saccharomyces cerevisiae YJM789)

LAEKTRSIIKATVPVLEQQGTVITRTFYKNMLTEHTELLNIFNRTNQKVG
AQPNALATTVLAAAKNIDDLSVLMDHVKQIGHKHRALQIKPEHYPIVGEY
LLKAIKEVLGDAATPEIINAWGEAYQAIADIFITVEKKMYEEALWPGWKP
FEITAKEYVASDIVEFTVKPKFGSGIELESLPITPGQYITVNTHPIRQEN
QYDALRHYSLCSASTKNGLRFAVKMEAARENFPAGLVSEYLHKDAKVGDE
IKLSAPAGDFAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQVKCNPNR
PIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKE
KSPAHADVYTCGSLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV

3D structure

• PDB: 4g1v Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole.
• Chain: A
• Resolution: 2.098 Å

Enzymatic activity

• Enzyme Commision number: 1.14.12.17: nitric oxide dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	I42 F43 N47 Q53 A56 I81 K84 H85 L88 I90 H94 Y95 V98 Y126 P392 K393 M394	I41 F42 N46 Q52 A55 I80 K83 H84 L87 I89 H93 Y94 V97 Y125 P391 K392 M393
BS02	FAD	A	T46 V50 K84 Y189 R207 H208 Y209 S210 A223 V224 E227 R230 F233 P234 G236 L237 V238 S239 V282 F390	T45 V49 K83 Y188 R206 H207 Y208 S209 A222 V223 E226 R229 F232 P233 G235 L236 V237 S238 V281 F389

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008941 nitric oxide dioxygenase NAD(P)H activity
• GO:0016491 oxidoreductase activity
• GO:0019825 oxygen binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0071949 FAD binding

Biological Process

• GO:0046210 nitric oxide catabolic process
• GO:0062197 cellular response to chemical stress
• GO:0071500 cellular response to nitrosative stress

External links

• PDB: RCSB:4g1v, PDBe:4g1v, PDBj:4g1v
• PDBsum: 4g1v
• PubMed: 23095020
• UniProt: A6ZUP2