Structure of PDB 4g0v Chain A

Receptor sequence

>4g0vA (length=663) Species: 9606 (Homo sapiens) [Search protein sequence]

KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFP
LRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGK
IMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITDMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAG
SVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKD
AASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVL
INGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTI
QELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDK
TPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN
NQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDF
NYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFV
EELDKVESQERED

3D structure

PDB

4g0v On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

Chain

Resolution

2.548 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E477 G504 K505 D561 R729 K739 Y773 H775 G776 T783 N786 I872	E26 G53 K54 D110 R214 K224 Y258 H260 G261 T268 N271 I357
BS02	dna	A	K456 D479 R503	K5 D28 R52
BS03	dna	A	K505 L507 N508 H564 F669 I674 R677 K678 S818 Y821 I872 G873 G875 W876 T1010 T1012 N1014 S1015	K54 L56 N57 H113 F164 I169 R172 K173 S303 Y306 I357 G358 G360 W361 T495 T497 N499 S500
BS04	MIX	A	R503 G504 K505 N520 E522 Q778	R52 G53 K54 N69 E71 Q263
BS05	MG	A	D557 D559	D106 D108

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4g0v, PDBe:4g0v, PDBj:4g0v
PDBsum	4g0v
PubMed	24038465
UniProt	Q02880\|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)

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