Structure of PDB 4fzi Chain A

Receptor sequence
>4fziA (length=277) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
YNCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYS
NERGVGQGIRESGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEY
IDLYLIHWPGKKKFVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSC
KIRPMVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGSGEEAGILKNHV
LGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTE
EEMRQIDELNEDKRIGADPDNFFPGGE
3D structure
PDB4fzi Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D48 Y53 K78 H111
Catalytic site (residue number reindexed from 1) D44 Y49 K74 H107
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A W24 Y53 H111 W188 W20 Y49 H107 W184
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0036130 prostaglandin H2 endoperoxidase reductase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fzi, PDBe:4fzi, PDBj:4fzi
PDBsum4fzi
PubMed25945716
UniProtQ4DJ07|PGFS_TRYCC 9,11-endoperoxide prostaglandin H2 reductase (Gene Name=Tc00.1047053511287.49)

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