Structure of PDB 4fxs Chain A

Receptor sequence
>4fxsA (length=467) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMD
TVTEARLAIALAQEGGIGFIHKNMSIEQQAAQVHQVKIFEAVTHPVTVRP
EQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAV
MTPKERLATVKEGEVQEKMHVEKILVVNDEFQLKGMITAKESKPNACKDE
QGRLRVGAAVGAAPGNEERVKALVEAGVDVLLIDSSHGHSEGVLQRIRET
RAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVG
VPQITAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMF
AGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGSSDRYFQTADKLVPEGI
EGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGM
KESHVHDVQITKEAPNY
3D structure
PDB4fxs Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae complexed with IMP and mycophenolic acid.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A M51 G304 S305 I306 C307 D340 G342 G363 S364 Y387 G389 M390 G391 E417 M49 G288 S289 I290 C291 D324 G326 G347 S348 Y371 G373 M374 G375 E398
BS02 MOA A D250 S251 S252 N279 G300 G302 T309 D234 S235 S236 N263 G284 G286 T293
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fxs, PDBe:4fxs, PDBj:4fxs
PDBsum4fxs
PubMed
UniProtQ9KTW3

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