Structure of PDB 4fxd Chain A

Receptor sequence
>4fxdA (length=848) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREG
KTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLL
PYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIK
GADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPK
ENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAA
LAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAH
RMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIA
NEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMA
LQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYI
LLHEFSRNGFIVPDKVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTT
VDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHK
RVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTR
QLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEI
DIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPLS
RDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMK
LSKDPKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKLSVAERAH
ALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALG
3D structure
PDB4fxd Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R793 V957 N958 R443 V575 N576
BS02 rna A K1047 K1069 G1070 R1075 R1076 M1131 K1132 S1134 K1135 Y1140 K665 K687 G688 R693 R694 M749 K750 S752 K753 Y758
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fxd, PDBe:4fxd, PDBj:4fxd
PDBsum4fxd
PubMed23599895
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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