Structure of PDB 4fx9 Chain A

Receptor sequence
>4fx9A (length=442) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MKKKVVIIGGGAAGMSAASRVKRLKPEWDVKVFEATEWVSHAPCGIPYVV
EGLSTPDKLMYYPPEVFIKKRGIDLHLNAEVIEVDTGYVRVRGGEKSYEW
DYLVFANGASPQVPAIEGVNLKGVFTADLPPDALAIREYMEKYKVENVVI
IGGGYIGIEMAEAFAAQGKNVTMIVRGERVLRRSFDKEVTDILEEKLKKH
VNLRLQEITMKIEGEERVEKVVTDAGEYKAELVILATGIKPNIELAKQLG
VRIGETGAIWTNEKMQTSVENVYAAGDVAETRHVITGRRVWVPLAPAGNK
MGYVAGSNIAGKELHFPGVLGTAVTKFMDVEIGKTGLTEMEALKEGYDVR
TAFIKASTRPHYYPGGREIWLKGVVDNETNRLLGVQVVGSDILPRIDTAA
AMLMAGFTTKDAFFTDLAYAPPFAPVWDPLIVLARVLKFLEH
3D structure
PDB4fx9 Structure and substrate specificity of the pyrococcal coenzyme A disulfide reductases/polysulfide reductases (CoADR/Psr): implications for S(0)-based respiration and a sulfur-dependent antioxidant system in Pyrococcus.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A16 V43 P47 C48 S58 D61 Y161 E165 N305 A424 A426 P431
Catalytic site (residue number reindexed from 1) A12 V39 P43 C44 S54 D57 Y155 E159 N299 A418 A420 P425
Enzyme Commision number 1.8.1.-
1.8.1.14: CoA-disulfide reductase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003756 protein disulfide isomerase activity
GO:0016491 oxidoreductase activity
GO:0050451 CoA-disulfide reductase (NADPH) activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding

View graph for
Molecular Function
External links
PDB RCSB:4fx9, PDBe:4fx9, PDBj:4fx9
PDBsum4fx9
PubMed23530771
UniProtO58308|NCPPR_PYRHO NAD(P)H coenzyme A polysulfide/persulfide reductase (Gene Name=PH0572)

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