Structure of PDB 4fws Chain A

Receptor sequence
>4fwsA (length=394) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
FPVVLVINCGSSSIKFSVLDVATCDVLMAGIADGMNTENAFLSINGDKPI
NLAHSNYEDALKAIAFELEKRDLTDSVALIGHRIAHGGELFTQSVIITDE
IIDNIRRVSPLAPLHNYANLSGIDAARHLFPAVRQVAVFDTSFHQTLAPE
AYLYGLPWEYFSSLGVRRYGFHGTSHRYVSRRAYELLDLDEKDSGLIVAH
LGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFGAMAWIAKETG
QTLSDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERARLAIKTFVHR
IARHIAGHAASLHRLDGIIFTGGIGENSVLIRQLVIEHLGVLGLTLDVEM
NKQPNSHGERIISANPSQVICAVIPTNEEKMIALDAIHLGNVKA
3D structure
PDB4fws Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies.
ChainA
Resolution2.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N11 R86 H175 R236 E381
Catalytic site (residue number reindexed from 1) N8 R83 H172 R233 E378
Enzyme Commision number 2.7.2.15: propionate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDO A V24 C27 V21 C24
BS02 EDO A H118 K265 H115 K262
BS03 EDO A N206 T235 R236 N203 T232 R233
BS04 CTP A G205 N206 G207 D278 L279 R280 G326 I327 N330 G202 N203 G204 D275 L276 R277 G323 I324 N327
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008776 acetate kinase activity
GO:0008980 propionate kinase activity
GO:0016301 kinase activity
GO:0016774 phosphotransferase activity, carboxyl group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006083 acetate metabolic process
GO:0016310 phosphorylation
GO:0070689 L-threonine catabolic process to propionate
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4fws, PDBe:4fws, PDBj:4fws
PDBsum4fws
PubMed23747922
UniProtO06961|TDCD_SALTY Propionate kinase (Gene Name=tdcD)

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