Structure of PDB 4fw8 Chain A

Receptor sequence
>4fw8A (length=427) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYD
LVGDSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPE
AAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLEST
MRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGA
TIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDKI
SEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLT
EGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPG
LAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEA
IAYFASPASNAVTGNVIRVCGQAMIGA
3D structure
PDB4fw8 Crystal structure of hexanoyl-CoA bound to beta-ketoacyl reductase FabG4 of Mycobacterium tuberculosis
ChainA
Resolution2.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S347 Y360 K364
Catalytic site (residue number reindexed from 1) S320 Y333 K337
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A G220 R223 I225 D244 L266 V268 N295 A296 G297 L345 Y360 K364 P390 G193 R196 I198 D217 L239 V241 N268 A269 G270 L318 Y333 K337 P363
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0030497 fatty acid elongation
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0046459 short-chain fatty acid metabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fw8, PDBe:4fw8, PDBj:4fw8
PDBsum4fw8
PubMed23163771
UniProtO53665

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