Structure of PDB 4fw7 Chain A

Receptor sequence
>4fw7A (length=301) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
NAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVV
EIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSAS
EVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVP
FDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIE
YLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYL
LGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMR
P
3D structure
PDB4fw7 Crystal Structure of the LpxC
ChainA
Resolution1.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H78 H237 D241 H80 H239 D243
BS02 L63 A M62 E77 T190 F191 I197 G209 S210 H237 D241 H264 M64 E79 T192 F193 I199 G211 S212 H239 D243 H266 BindingDB: Kd=74.5nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fw7, PDBe:4fw7, PDBj:4fw7
PDBsum4fw7
PubMed
UniProtP47205|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

[Back to BioLiP]